Bellen Lab

Hwei-Jan Hsu

Hwei-Jan Hsu

Research Fellow, Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan
Postdoctoral Research Fellow, Department of Cell and Developmental Biology, Vanderbilt University Medical Center, USA
Ph.D. ,Institute of Life Science, National Defense Medical Center, Taiwan

Research Interests

I am interested in exploring the connection between metabolism and cellular signaling in regulating cell function. My research focuses on leveraging dietary interventions to modulate cellular metabolism, with the goal of treating metabolic disorders and delaying aging.

Publications

Huang WH*, Kajal K*, Himawan Wibowo R, Amartuvshin O, Kao SH, Rastegari E, Lin CH, Chiou KL, Pi HW, Ting C#, Hsu HJ#  (2024) Excess Dietary Sugar Imparis Drosophila Adult Stem Cell via Elevated ROS-JNK Signaling. Development 151(1):dev201772. # co-corresponding * equal contribution This article is selected as a Research Highlight [Abstract]
Fung CT, Kuo HH, Amartuvshin O, Hsu HJ, Liu SL, Yao JS, Yih LH (2023) Inhibition of acetyl-CoA carboxylase impaired tubulin palmitoylation and induced spindle abnormalities. Cell Death Discovery 9(1):4.  [Abstract]
Lin CH, Lin TY, Hsu SC, Hsu HJ (2022) Expansion Microscopy-based imaging for visualization of mitochondria in Drosophila ovarian germline stem cells. FEBS Open Bio 12(12):2102-2110.  [Abstract]
Chen TA, Lin KY, Yang SM, Tseng CY, Wang YT, Lin CH, Luo L, Cai Y, Hsu HJ (2022) Canonical Wnt signaling promotes the formation of somatic permeability barrier for proper germ cell differentiation. Front Cell Dev Biol 10:877047.  [Abstract]
Tseng TL, Wang YT, Tsao CY, Ke YT, Lee YC, Hsu HJ, Poss KD, Chen CH  (2021) The RNA helicase Ddx52 functions as a growth switch in juvenile zebrafish. Development 148(15):dev199578.  [Abstract]
Amartuvshin O, Lin CH, Hsu SC, Kao SH, Chen A, Tang WC, Chou HL, Chang DL, Hsu YY, Hsiao BS, Rastegari E, Lin KY, Wang YT, Yao CK, Chen GC, Chen BC, Hsu HJ  (2020) Aging shifts mitochondrial dynamics toward fission to promote germline stem cell loss. Aging Cell 19(8):e13191.  [Abstract]
Lin KY, Wang WD, Lin CH, Rastegari E, Su YH, Chang YC, Chang YT, Liao YF, Pi HW, Yu BY, Chen SH, Lin CY, Lu MY, Su TY, Tzou FY, Chan CC, Hsu HJ (2020) Piwi Reduction in the Aged Niche Eliminates Germline Stem Cells via Toll-GSK3 Signaling. Nat Commun 11(1):3147.  [Abstract]
Lin KY, Hsu HJ  (2020) Regulation of adult female germline stem cells by nutrient-responsive signaling. Curr Opin Insect Sci 37:16-22.  [Abstract]
Rastegari E, Kajal K, Tan BS, Huang F, Chen RH, Hsieh TS, Hsu HJ (2020) WD40 protein Wuho controls germline homeostasis via TRIM-NHL tumor suppressor Mei-p26 in Drosophila. Development 147(2):dev182063.  [Abstract]
Hsu HJ, Bahader M, Lai CM (2019) Molecular control of the female germline stem cell niche size in Drosophila. Cell Mol Life Sci 76(21):4309-4317.  [Abstract]
Ke YT, Hsu HJ (2019) Generation of Inducible Gene-Switched GAL4 Expressed in the Drosophila Female Germline Stem Cell Niche. G3 9(6):2007-2016.  [Abstract]
Tseng CY, Su YH, Yang SM, Lin KY, Lai CM, Rastegari E, Amartuvshin O, Cho Y, Cai Y, Hsu HJ (2018) Smad-independent BMP signaling in somatic cells limits the size of the germline stem cell pool during ovary development. Stem Cell Reports 11(3):811-827.  [Abstract]
Cho Y, Lai CM, Lin KY, Hsu HJ (2018) A targeted RNAi screen reveals Drosophila female-sterile genes that control the size of the germline stem cell niche during development. G3 8(7):2345-2354.  [Abstract]
Su YH, Rastegri E, Kao SH, Lai CM, Lin KY, Liao HY, Wang MH, Hsu HJ (2018) Diet Regulates Membrane Extension and Survival of Niche Escort Cell for Germline Homeostasis via Insulin signaling. Development 145(7):dev159186.  [Abstract]
Tseng CY, Hsu HJ (2017) Decreased expression of lethal giant larvae causes ovarian follicle cell outgrowth in the Drosophila Scutoid mutant. PLOS one 12(12):e0188917.  [Abstract]
Lai CM, Lin KY, Kao SH, Chen YN, Huang F, Hsu HJ (2017) Cell Adhesion Controlled by Hedgehog Signaling Establishes Precursors for Germline Stem Cell Niches. J Cell Biol 216(5):1439-1453.  [Abstract]
Hsu HJ, Drummond-Barbosa D  (2017) A visual screen for diet-regulated proteins in the Drosophila ovary using GFP protein trap lines. Gene Expression Patterns 23-24:13-21.  [Abstract]
Wang WD, Hsu HJ, Li YF, Wu CY  (2017) Retinoic Acid Protects and Rescues the Development of Zebrafish Embryonic Retinal Photoreceptor Cells from Exposure to Paclobutrazol. International Journal of Molecular Science 18(1):130.  [Abstract]
Tseng CY, Kao SH, Hsu HJ (2016) Snail control proliferation of follicle stem cells, indepedently of E-cadherin. Developmental Biology 414(2):412-418.  [Abstract]
Lin KY, Kao SH, Lai CM, Chen CTM, Wu CY, Hsu HJ*, Wang WD *  (2015) Tumor Suppressor Lzap Suppresses Wnt/b-catenin Signaling to Promote Zebrafish Embryonic Ventral Cell Fates via the Suppression of Inhibitory Phosphorylation of GSK3. Journal of Biological Chemistry 290(50):29808-19.  [Abstract]
Lin JC, Hu S, Ho PH, Hsu HJ, Postletheait J, Chung BC  (2015) Two zebrafish hsd3b genes are distinct in functions, expression and evolution. Endocrinology :en20141584.  [Abstract]
Wang WD, Chen GT, Hsu HJ, Wu CY  (2015) Aryl hydrocarbon receptor 2-mediates the toxicity of Paclobutrazol on the digestive system of zebrafish embryos. Aquatic Toxicology 159:13-22.  [Abstract]
Kao SH, Tseng CY, Wan CL, Su YH, Hsieh CC, Pi H, Hsu HJ (2015) Aging and insulin signaling differentially control normal and tumorous germline stem cells. Aging Cell 14(1):25-34.  [Abstract]
Tseng CY, Kao SH, Wan CL, Cho Y, Tung SY, Hsu HJ  (2014) Notch signaling mediates the age-associated decrease in adhesion of germline stem cells to the niche. PLOS Genetics 10(12):e1004888.  [Abstract]
Yekti AP, Hsu HJ, Wang WD  (2014) The effect of paclobutrazol on the development of zebrafish (Danio rerio) embryos. Zebrafish 11:1-9.  [Abstract]
Yang SA, Wang WD, Chen CT, Tseng CY, Chen YN, Hsu HJ  (2013) FOXO/Fringe is necessary for maintenance of the germline stem cell niche in response to insulin insufficiency. Developmental Biology 382:124-135.  [Abstract]
Hsu HJ, Drummond-Barbosa D  (2011) Insulin signals control the competence of the Drosophila female germline stem cell niche to respond to Notch ligands. Developmental Biology 350:290-300.  [Abstract]
Tong SK, Hsu HJ, Chung BC  (2010) Zebrafish monosex population reveals female dominance in sex determination and earliest events of gonad differentiation. Developmental Biology 344:849-856.  [Abstract]
LaFever L, Feoktistov A, Hsu HJ, Drummond-Barbosa D (2010) Specific roles of Target of rapamycin in the control of stem cells and their progeny in the Drosophila ovary. Development 137:2117-2126.  [Abstract]
Hsu HJ, Lin JC, Chung BC  (2009) Zebrafish cyp11a1 and hsd3b genes: structure, expression and steroidogenic development during embryogenesis. Molecular and cellular endocrinology 312:31-34.  [Abstract]
Hsu HJ, Drummond-Barbosa D  (2009) Insulin levels control female germline stem cell maintenance via the niche in Drosophila. Proceedings of the National Academy of Sciences of the United States of America 106:1117-1121.  [Abstract]
Hsu HJ, LaFever L, Drummond-Barbosa D (2008) Diet controls normal and tumorous germline stem cells via insulin-dependent and -independent mechanisms in Drosophila. Developmental Biology 313:700-712.  [Abstract]
Hsu HJ, Liang MR, Chen CT, Chung BC (2006) Pregnenolone stabilizes microtubules and promotes zebrafish embryonic cell movement. Endocrine research 30:803.  [Abstract]
Hsu HJ, Hsu NC, Hu MC, Chung BC (2006) Steroidogenesis in zebrafish and mouse models. Molecular and cellular endocrinology 248:160-163.  [Abstract]
Hsu HJ, Lin G, Chung BC (2004) Parallel early development of zebrafish interrenal glands and pronephros: differential control by wt1 and ff1b. Endocrine research 30:803.  [Abstract]
Hsu HJ, Lin G, Chung BC (2003) Parallel early development of zebrafish interrenal glands and pronephros: differential control by wt1 and ff1b. Development 130:2107-2116.  [Abstract]
Hsu HJ, Hsiao P, Kuo MW, Chung BC (2002) Expression of zebrafish cyp11a1 as a maternal transcript and in yolk syncytial layer. Gene expression patterns : GEP 2:219-222.  [Abstract]
Hsu HJ, Wang WD, Hu CH  (2001) Ectopic expression of negative ARNT2 factor disrupts fish development. Biochemical and biophysical research communications 282:487-492.  [Abstract]
Wang WD, Wu JC, Hsu HJ, Kong ZL, Hu CH  (2000) Overexpression of a Zebrafish ARNT2-like Factor Represses CYP1A Transcription in ZLE Cells. Marine Biotechnology 2:376-386.  [Abstract]
Last Modified 12-04-2023

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