Ali Hosseini Bereshneh

I am interested in studying rare and undiagnosed neurogenetic disorders based on sequencing data, bioinformatic analyses, molecular dynamic simulations, and animal modeling. In collaboration with scientists and researchers in the Bellen Lab, we generate models for undiagnosed disorders in Drosophila to probe the affected molecular pathways and participate in gene discovery. We create mutations in flies of the human homologues genes using CRISPR technology, determine the expression pattern of genes and determine where the proteins are localized, attempt rescue of the fly mutants with the human reference cDNA, and assess if the variants found in the patients fail to rescue the mutants. These studies also rely on metabolomic studies, behavioral experiments, electrophysiological experiments, single-cell sequencing data, as well as proteomic studies.