Bellen Lab

Ali Hosseini Bereshneh

Ali Hosseini Bereshneh

B.Sc, Mashhad University of Medical Sciences, Iran
M.Sc, Tehran University of Medical Sciences, Iran
PhD, Tarbiat Modares University (TMU), Iran

Research Interests

I am interested in studying rare and undiagnosed neurogenetic disorders based on sequencing data, bioinformatic analyses, molecular dynamic simulations, and animal modeling. In collaboration with scientists and researchers in the Bellen Lab, we generate models for undiagnosed disorders in Drosophila to probe the affected molecular pathways and participate in gene discovery. We create mutations in flies of the human homologues genes using CRISPR technology, determine the expression pattern of genes and determine where the proteins are localized, attempt rescue of the fly mutants with the human reference cDNA, and assess if the variants found in the patients fail to rescue the mutants. These studies also rely on metabolomic studies, behavioral experiments, electrophysiological experiments, single-cell sequencing data, as well as proteomic studies.


Publications

Gholamreza Z, Hosseinpour S, Ashrafi MR, Mohammadi M, Badv RS, Tavasoli AR, Akbari MG, Hosseini Bereshneh A, Malamiri RA, Heidari M (2022) Characteristics of Disease Progression and Genetic Correlation in Ambulatory Iranian Boys with Duchenne Muscular Dystrophy. BMC Neurology 22(1):162.  [Abstract]
Fatemeh R*, Hosseini Bereshneh A*, Ramezanzadeh M, Garshasbi M (2022) Novel compound heterozygous variants in XYLT1 gene caused Desbuquois dysplasia type 2 in an aborted fetus: a case report. BMC Pediatrics 22(1):1-6. *contributed equally [Abstract]
Hosseini Bereshneh A, Jafarinia E, Rajabi F, Ashrafi MR, Tavasoli AR, Garshasbi M (2021) Crystallographic modeling of the PNPT1: c. 1453A> G variant as a cause of mitochondrial dysfunction and autosomal recessive deafness; expanding the neuroimaging and clinical features. Mitochondrion 59:1-7.  [Abstract]
Mohamad P, Hessami K, Inaloo S, Nemati H, Katibeh P, Nejabat M, Darabi MH, Hosseini Bereshneh A (2021) Case report of RANBP2 mutation and familial acute necrotizing encephalopathy. International Journal of Pediatrics :doi: 10.1155/2021/6695119.  [Abstract]
Masoudi M, Hosseini Bereshneh A, Rasoulinezhad M, Ashrafi MR, Garshasbi M, Tavasoli AR (2020) Leukoencephalopathy in Al-Raqad Syndrome: Expanding the clinical and neuroimaging features caused by a biallelic novel missense variant in DCPS. American journal of medical genetics 182(10):2391-2398.  [Abstract]
Gholamreza Z, Hosseini Bereshneh A, Malamiri RA, Bagheri S, Moradi K, Ashrafi MR, Tavasoli AR, Mohammadi M, Badv RS, Akbari MG, Heidari M (2020) The first comprehensive cohort of the Duchenne muscular dystrophy in Iranian population: mutation spectrum of 314 patients and identifying two novel nonsense mutations. Journal of Molecular Neuroscience 70(10):1565-1573.  [Abstract]
Hosseini Bereshneh A, Hosseipour S, Rasoulinezhad MS, Pak N, Garshasbi M, Tavasoli AR (2020) Expanding the clinical and neuroimaging features of NKX6-2-related hereditary spastic ataxia type 8. European Journal of Medical Genetics 63(5):103868.  [Abstract]
Hosseini Bereshneh A, Garshasbi M (2018) Novel in-frame deletion in MFSD8 gene revealed by trio whole exome sequencing in an Iranian affected with neuronal ceroid lipofuscinosis type 7: a case report. Journal of Medical Case Reports 12(1):281.  [Abstract]
Salmaninejad A, Zamani MR, Pourvahedi M, Golchehre Z, Hosseini Bereshneh A, Rezaei N (2016) Cancer/testis antigens: expression, regulation, tumor invasion, and use in immunotherapy of cancers. Immunological investigations 45(7):619-640.  [Abstract]

Last Modified 12-02-2022

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