Bellen Lab

Debdeep Dutta

Debdeep Dutta

BSc, University of Burdwan, West-Bengal, India
MSc, Banaras Hindu University, India
PhD, Banaras Hindu University, India (Ashim Mukherjee)

Research Interests

My research interest is to understand the pathobiology of rare and undiagnosed neurological diseases. By taking advantage of next-generation sequencing data of the patients and the success of variant functional assessment using the humanized fruit-fly model, I will identify novel human disease genes. Importantly, I will further dissect the biological mechanisms of these new disease genes with a particular focus on mitochondria and conserved signaling pathways. Unraveling the biology of rare neurological conditions can be immensely helpful for the therapeutic development and proper disease management; and, it will also shed light on more common disease mechanisms.

Publications

Dutta D, Kanca O, Shridharan RV, Marcogliese PC, Steger B, Morimoto M, Frost FG, Macnamara E; Undiagnosed Diseases Network; Wangler MF, Yamamoto S, Jenny A, Adams D, Malicdan MC, Bellen HJ (2024) Loss of the endoplasmic reticulum protein Tmem208 affects cell polarity, development, and viability. Proceedings of the National Academy of Science Sci U S A 121(9):e232258212.  [Abstract]
Ma M, Zheng Y, Lu S, Pan X, Worley KC, Burrage LC, Blieden LS, Allworth A, Chen WL, Merla G, Mandriani B, Rosenfeld JA, Li-Kroeger D, Dutta D, Yamamoto S, Wangler MF; Undiagnosed Diseases Network; Glass IA, Strohbehn S, Blue E, Prontera P, Lalani SR, Bellen HJ (2024) De novo variants in PLCG1 are associated with hearing impairment, ocular pathology, and cardiac defects. medRxiv :10.1101/2024.01.08.23300523.  [Abstract]
Dutta D, Kanca O, Byeon SK, Marcogliese PC, Zuo Z, Shridharan RV, Park JH, Undiagnosed Diseases Network, Lin G, Ge M, Heimer G, Kohler JN, Wheeler MT, Kaipparettu BA, Pandey A, Bellen HJ (2023) A defect in mitochondrial fatty acid synthesis impairs iron metabolism and causes elevated ceramide levels. Nature Metabolism 5(9):1595-1614.  [Abstract]
Pan X, Dutta D, Lu S, Bellen HJ (2023) Sphingolipids in neurodegenerative diseases. Frontiers in Neuroscience 17:1137893.  [Abstract]
Ray SS, Dutta D, Dennys C, Powers S, Roussel F, Lisowski P, Glazar P, Zhang X, Biswas P, Caporale JR, Rajewsky N, Bickle M, Wein N, Bellen HJ, Likhite S, Marcogliese PC, Meyer KC (2022) Mechanisms of IRF2BPL-related disorders and identification of a potential therapeutic strategy. Cell Reports 41:111751.  [Abstract]
Kanca O, Zirin J, Hu Y, Tepe B, Dutta D, Lin WW, Ma L, Ge M, Zuo Z, Liu LP, Levis RW, Perrimon N, Bellen HJ (2022) An expanded toolkit for Drosophila gene tagging using synthesized homology donor constructs for CRISPR mediated homologous recombination. eLife :DOI: 10.7554/eLife.76077.  [Abstract]
Marcogliese PC*#, Dutta D*, Sinha-Ray S, Dang NDP, Zuo Z, Wang Y, Lu D, Fazal F, Ravenscroft TA, Chung HL, Kanca O, Wan J, Douine ED, Pena LDM, Yamamoto S, Nelson SF, Might M, Meyer KC, Yeo NC, Bellen HJ# (2022)  Loss of IRF2BPL impairs neuronal maintenance through excess Wnt signaling. Science Advances :DOI: 10.1126/sciadv.abl5613 (*co-first authors and #co-corresponding authors).  [Abstract]
Goodman LD, Cope H, Nil Z, Ravenscroft, TA, Charng WL, Lu S, Tien AC, Pfundt R, Koolen DA, Haaxma CA, Veenstra-Knol HE, Wassink-Ruiter JSK, Wevers MR, Jones M, Walsh LE, Klee VH, Theunis M, Legius E, Steel D, Barwick KES, Kurian MA, Mohammad SS, Dale RC, Terhal PA, van Binsbergen E, Kirmse B, Robinette B, Cogne B, Isidor B, Grebe TA, Kulch P, Hainline BE, Sapp K, Morava E, Klee EW, Macke EL, Trapane P, Spencer C, Si Y, Begtrup A, Moulton MJ, Dutta D, Kanca O, UDN Consortia, Wangler MF, Yamamoto S, Bellen HJ*, Tan QKG*  (2021) De novo TNPO2 variants are associated with developmental delays, neurologic deficits and dysmorphic features in humans and alter TNPO2 activity in Drosophila. American Journal of Human Genetics 108(9):1669-1691. *equal contribution [Abstract]
Dutta D, Sharma V, Mutsuddi M, Mukherjee A (2021) Regulation of Notch signaling by E3 ubiquitin ligases. FEBS J :10.1111/febs.15792.  [Abstract]
Dutta D, Briere LC, Kanca O, Marcogliese PC, Walker MA, High FA, Vanderver A, Krier J, Carmichael N, Callahan C, Taft RJ, Simons C, Helman G, The Undiagnosed Diseases Network, Wangler MF, Yamamoto S, Sweetser DA, Bellen HJ (2020)  De novo mutations in TOMM70, a receptor of the mitochondrial import translocase, cause neurological impairment. Human Molecular Genetics 29(9):1568-1579.  [Abstract]
Dutta D, Mutsuddi M, Mukherjee A. (2020) Regulation of Notch Signaling in Drosophila melanogaster: The Role of the Heterogeneous Nuclear Ribonucleoprotein Hrp48 and Deltex. Adv Exp Med Biol 1227:95-105.  [Abstract]
Singh A, Paul MS, Dutta D, Mutsuddi M, Mukherjee A (2019) Regulation of Notch signaling by the chromatin-modeling protein Hat-trick. Development 146:1-11.  [Abstract]
Dutta D, Mutsuddi M, Mukherjee A (2018) Synergistic interaction of Deltex and Hrp48 leads to JNK activation. Cell Biology International 43:350-357.  [Abstract]
Paul MS, Dutta D, Singh A, Mutsuddi M, Mukherjee A (2018) Regulation of Notch signaling in the developing Drosophila eye by a T-box containing transcription factor, Dorsocross. Genesis 56:e23251.  [Abstract]
Dutta D, Singh A, Paul MS, Sharma V, Mutsuddi M, Mukherjee A (2018) Deltex interacts with Eiger and consequently influences the cell death in Drosophila melanogaster. Cellular Signalling 49:17-29.  [Abstract]
Paul MS, Singh A, Dutta D, Mutsuddi M, Mukherjee A (2018) Notch signals modulate lgl mediated tumorigenesis by the activation of JNK signaling. BMC Research Notes 11:247.  [Abstract]
Singh A, Dutta D, Paul MS, Verma D, Mutsuddi M, Mukherjee A (2018) Pleiotropic functions of the chromodomain-containing protein Hat-trick during oogenesis in Drosophila melanogaster. G3 (Bethesda) 8:1067-1077.  [Abstract]
Dutta D, Paul MS, Singh A, Mutsuddi M, Mukherjee A (2017) Regulation of Notch signaling by the heterogeneous nuclear ribonucleoprotein Hrp48 and Deltex in Drosophila melanogaster. Genetics 206:905-918.  [Abstract]
Last Modified 12-04-2023

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