Bellen Lab

Guang Lin

Guang Lin

BS, National Taiwan Ocean University
MS, National Taiwan Ocean University
PhD, Stony Brook University/CSHL (Nicholas Tonks)

Research Interests

I am interested in studying the molecular function of genes that cause neurodegenerative diseases. In collaboration with other members in the lab, my research has focused on VAPB, frataxin and PLA2G6, which cause Amyotrophic Lateral Sclerosis (ALS), Friedreich's Ataxia (FA) and Neurodegeneration with brain iron accumulations (NBIAs), respectively. We have generated Drosophila loss-of-function mutations for each of them and are currently studying the phenotypes associated with loss of these genes. By studying the molecular mechanisms that underlie the identified phenotypes, we hope to gain insight in the clinical pathology of these neurodegenerative diseases.


Lin G ,Tepe B , McGrane G, Tipon RC, Croft G, Panwala L, Hope A, Liang AJH, Zuo Z, Wang L, Bellen HJ (2023) Exploring therapeutic strategies for Infantile Neuronal Axonal Dystrophy (INAD/PARK14). eLife :doi: 10.7554/eLife.82555.  [Abstract]
Wang L, Lin G, Zuo Z, Li Y, Byeon SK, Pandey A, Bellen HJ (2022) Neuronal activity induces Glucosylceramide that is secreted via exosomes for lysosomal degradation in glia. Science Advances :DOI: 10.1126/sciadv.abn3326.  [Abstract]
Şentürk M, Lin G, Mao D, Zuo Z, Watson E, Mikos AG, Bellen HJ (2019) Ubiquilins regulate autophagic flux through mTOR signaling and lysosomal acidification. Nature Cell Biology 21:384-396.  [Abstract]
Mao D, Lin G, Tepe B, Zuo Z, Tan KL, Senturk M, Zhang S, Arenkiel BR, Sardiello M, Bellen HJ (2019) VAMP associated proteins are required for autophagic and lysosomal degradation by promoting a PtdIns4P-mediated endosomal pathway. Autophagy 11:1-20.  [Abstract]
Lin G, Wang L, Marcogliese PC, Bellen HJ (2018) Sphingolipids in the pathogenesis of Parkinson's disease and parkinsonism. Trends in Endocrinology & Metabolism 30:106-117.  [Abstract]
Lin G, Lee PT, Chen K, Mao D, Tan KL, Zuo Z, Lin WW, Wang L, Bellen HJ (2018) Phospholipase PLA2G6, a Parkinsonism-associated gene, affects Vps26 and Vps35, retromer function, and ceramide levels, similar to α-Synuclein gain. Cell Metabolism 28:605-618.  [Abstract]
Tan KL, Haelterman NA, Kwartler CS, Regalado ES, Lee PT, Nagarkar-Jaiswal S, Guo DC, Duraine L, Wangler MF, University of Washington Center for Mendelian Genomics, Bamshad MJ, Nickerson DA, Lin G, Milewicz DM, Bellen HJ (2018) Ari-1 regulates myonuclear organization together with Parkin and is associated with aortic aneurysms. Developmental Cell 45:226-244.  [Abstract]
Lee PT, Lin G, Lin WW, Diao F, White BH, Bellen HJ (2018) A kinase-dependent feedforward loop affects CREBB stability and long term memory formation. eLife 7:e33007.  [Abstract]
Lin G*, Mao D*, Bellen HJ (2017) Amyotrophic Lateral Sclerosis pathogenesis converges on defects in protein homeostasis associated with TDP-43 mislocalization and proteasome-mediated degradation overload. Current Topics in Developmental Biology 121:111-171. (*equal contribution) [Abstract]
Chen K, Ho TS, Lin G, Tan KL, Rasband MN, Bellen HJ (2016) Loss of Frataxin activates the iron/sphingolipid/PDK1/Mef2 pathway in mammals. eLife 5:e20732.  [Abstract]
Chen K, Lin G, Haelterman NA, Ho TS, Li T, Li Z, Duraine L, Graham BH, Jaiswal M, Yamamoto S, Rasband MN, Bellen HJ (2016) Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration. eLife 5:e16043.  [Abstract]
Li T, Fan J, Blanco-Sánchez B, Giagtzoglou N, Lin G, Yamamoto S, Jaiswal M, Chen K, Zhang J, Wei W, Lewis MT, Groves AK, Westerfield M, Jia J, Bellen HJ (2016) Ubr3, a novel modulator of Hh signaling affects the degradation of Costal-2 and Kif7 through poly-ubiquitination. PLoS Genetics 12:e1006054.  [Abstract]
Fan G, Lin G, Lucito R, Tonks NK (2013) Protein-tyrosine phosphatase 1B antagonized signaling by insulin-like growth factor-1 receptor and kinase BRK/PTK6 in ovarian cancer cells. Journal of Biological Chemistry 288:24923-24934.  [Abstract]
Yu M, Lin G, Arshadi N, Kalatskaya I, Xue B, Haider S, Nguyen F, Boutros PC, Elson A, Muthuswamy LB, Tonks NK, Muthuswamy SK (2012) Expression profiling during mammary epithelial cell three-dimensional morphogenesis identifies PTPRO as a novel regulator of morphogenesis and ErbB2-mediated transformation. Molecular Cell 32:3913-3924.  [Abstract]
Lin G, Aranda V, Muthuswamy SK, Tonks NK (2011) Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'. Genes and Development 25:1412-1425.  [Abstract]
Lan HC, Li HJ, Lin G, Lai PY, Chung BC (2007) Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylation. Molecular and Cellular Biology 27:2027-2036.  [Abstract]
Sun KH, Sun GH, Tsai CY, Wang HH, Chang CI, Lin G, Lin WW, Tang SJ (2005) Expression, purification, refolding, and characterization of recombinant human soluble-Fas ligand from Escherichia coliEnzyme and Microbial Technology 36:527-534.   
Hsu HJ, Lin G, Chung BC (2003) Parallel early development of zebrafish interrenal glands and pronephros: differential control by wt1 and ff1bDevelopment 130:2107-2116.  [Abstract]
Tang SJ, Sun KH, Sun GH, Lin G, Lin WW, Chuang MJ (1999) Cold-induced ependymin expression in zebrafish and carp brain: implications for cold acclimation. FEBS Letters 459:95-99.  [Abstract]

Last Modified 02-09-2023

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