Bellen Lab - Jennifer Deger

Research Interests

I want to help unravel the mechanisms underlying neurodegenerative diseases that occur with aging, especially Alzheimer's disease. Flies are an incredibly powerful model organism to study human disease. They are extremely genetically tractable, they have complex behaviors and a true central nervous system, and you don't have to wait very long for a fly to get very old! I'm especially interested in how glial biology and the blood-brain barrier change in fly models of Alzheimer's disease and how we can use that knowledge to help human patients.

Publications

: Deger J, Goethe E, LoPresti M, Lam S (2021) Intraventricular Hemorrhage Treatment in Premature Newborns: A Historical Review. World Neurosurgery 21:S1878-8750. [Abstract]; Rousseaux G, Vazquez-Velez G, Al-Ramahi I, Jeong H, Baji A, Revelli J, Ye H, Phan E, Deger J, Perez A, Kim J, Lavery L, Xu Q, Li M, Kang H, Kim J, Shulman J, Westbrook T, Elledge S, Liu Z, Botas J, Zoghbi H (2018) A druggable genome screen identifies modifiers of alpha-synuclein levels via a tiered cross-species validation approach. Journal of Neuroscience 38:9286-9301. [Abstract]; Deger J, Gerson J, Kayed R. (2015) The interrelationship of proteasome impairment and oligomeric intermediates in neurodegeneration. Aging Cell 14:715-24. [Abstract]

Jennifer Deger

Research Interests

Publications

Last Modified 02-09-2023