Bellen Lab

Mingxue Gu

Mingxue Gu

BS, Peking University, China
PhD, University of Michigan, Ann Arbor (Haoxing Xu)

Research Interests

My research interest lies in understanding how dysregulation of lysosomal signaling pathways and lysosome physiology contribute to neurological and neurodegenerative diseases. Using Drosophila Melanogaster as a model, I am investigating the roles of lysosomal genes in the pathogenesis and progression of Alzheimer's and Parkinson's diseases, and seeking to identify potential therapeutic targets.


Ravenscroft TA, Jacobs A, Gu M, Eberl DF, Bellen HJ (2023) The Voltage-gated sodium channel in Drosophila, Para, localizes to dendrites as well as axons in mechanosensitive chordotonal neurons. eNeuro :in press.  [Abstract]
Zhang X*, Gu M*, Hu M*, Yang Y, and Xu H. (2020) Endosomal and lysosomal electrophysiology. Ion and Molecule Transport in Lysosomes 117(46):29155-29165. *equal contribution  
Li P, Hu M, Wang C, Feng X, Zhao Z, Yang Y, Sahoo N, Gu M, Yang Y, Xiao S, Sah R, Cover T, Chou J, Geha R, Benavides F, Hume R and Xu H. (2020) LRRC8 family proteins within lysosomes regulate cellular osmoregulation and enhance cell survival in response to multiple physiological stresses. Proceedings of the National Academy of Sciences 117(46):29155-29165.  [Abstract]
Li P*, Gu M*, Xu H. (2019) Lysosomal ion channels as decoders of cellular signals. Trends in Biochemical Sciences 44(2):110-124. *equal contribution [Abstract]
Yang J, Zhao Z, Gu M, Feng X, Xu H. (2019) Release and uptake mechanisms of vesicular Ca2+ stores. Protein Cell 10(1):8-19.  [Abstract]
Sahoo N, Gu M, Zhang X, Raval N, Yang J, Bekier M, Calvo R, Patnaik S, Wang W, King G, Samie M, Gao Q, Sahoo S, Sundaresan S, Keeley TM, Wang Y, Marugan J, Ferrer M, Samuelson LC, Merchant JL, Xu H. (2017) Gastric acid secretion from parietal cells is mediated by a Ca2+ efflux channel in the tubulovesicle. Developmental Cell 41(3):262-273.  [Abstract]
Wang W, Zhang X, Gao Q, Lawas M, Yu L, Cheng X, Gu M, Sahoo N, Li X, Li P, Ireland S, Meredith A, Xu H. (2017) A voltage-dependent K+ channel in the lysosome is required for refilling lysosomal Ca2+ stores. Journal of Cell Biology 216(6):1715-1730.  [Abstract]
Gu M, Xu H. (2016) A painful TR(i)P to lysosomes. Journal of Cell Biology 215(3):309-312.  [Abstract]
Sun X, Wu Y, Gu M, Liu Z, Ma Y, Li J, Zhang Y. (2014) Selective filtering defect at the axon initial segment in Alzheimer's disease mouse models. Proceedings of the National Academy of Sciences 111(39):14271-6.  [Abstract]
Sun X, Wu Y, Gu M, Zhang Y. (2014) MiR-342-5p Decreases Ankyrin G level in Alzheimer's disease transgenic mouse models. Cell Reports 6(2):264-270.  [Abstract]

Last Modified 12-04-2023

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