Bellen Lab

Prajakta Deshpande

Prajakta Deshpande

BSc. in Biotechnology, Genetics and Biochemistry, Garden City College, Bangalore, India
MSc. in Biochemistry, University of Hyderabad, Hyderabad, India
PhD. in Biological Sciences, University of Dayton, Ohio, USA

Research Interests

I am interested in understanding the underlying mechanism of neurodegenerative diseases and rare and undiagnosed neurological diseases. Drosophila is an ideal model system to study human diseases. My research focuses on identifying novel human disease genes by using humanized fly models, further dissecting the disease-causing mechanisms and exploring the potential therapeutic strategies


Deshpande P, Chen C-Y, Li J-C, Sarkar A, Yeates C, Chen C-H, Kango-Singh M, Singh A (2024) miR-277 targets the proapoptotic gene-hid to ameliorate AB42-mediated neurodegeneration in Alzheimer's model. Cell Death and Disease 15(1):71.  [Abstract]
Deshpande P, Chimata AV, Snider E, Singh A, Kango-Singh M, Singh A (2023) N-Acetyltransferase 9 ameliorates ABeta 42-mediated neurodegeneration in Drosophila eye. Cell Death and Disease 14(7):478.  [Abstract]
Yeates C, Deshpande P, Kango-Singh M, Singh A (2023) Signaling interactions among neurons impact cell fitness and death in Alzheimer's disease. Neural Regeneration Research 18(4):784-9.  [Abstract]
Singh A#, Deshpande P#, Chimata AV#, Sangeeth A, Bajpai S, Subramanian M, Padma R, Singh A (2023) Factors influencing protein misfolding and aggregate formation that trigger neuronal cell death. Protein Misfolding and Neurodegenerative Diseases :.  
Chimata AV, Deshpande P, Mehta AS, Singh A (2022) Protocol to study cell death using TUNEL assay in Drosophila imaginal discs. STAR Protocol 3(1):101140.  [Abstract]
Deshpande P, Chimata AV, Labya E, Singh A (2022) Studying cell proliferation profile in pupal retina model of Drosophila melanogaster. Drosophila Information Service 103:.  
Mehta AS, Deshpande P, Chimata AV, Tsonis PA, Singh A (2021) Newt regeneration genes regulate Wingless signaling to restore patterning in Drosophila eye. iScience 24(10):103166.  [Abstract]
Deshpande P#, Gogia N#, Chimata AV#, Singh A (2021) Unbiased automated quantitation of ROS signals in live retinal neurons of Drosophila using Fiji/ImageJ. Biotechniques 71(2):416-24.  [Abstract]
Gupta V*, Agarwal P, Deshpande P (2021) Impact of RASSF1A gene methylation on clinic-pathological features of tumor and non-tumor tissue of breast cancer. Annals of Diagnostic Pathology 52:151722.  [Abstract]
Gogia N#, Chimata AV#, Deshpande P#, Singh A, Singh A (2021) Hippo signaling: bridging the gap between cancer and neurodegenerative disorders. Neural Regeneration Research 16(4):643-52. # equal contribution [Abstract]
Chimata AV#, Deshpande P#, Singh A (2021) Impact of Aging at Cellular and Organ Level. Anti-Aging drug discovery on the basis of Hallmark of Aging :.  
Chimata AV, Mehta AS, Jento S, Deshpande P, Singh A (2021) Transcriptomics and genetic engineering. Transcriptome profiling: progress and prospects :.  
Yeates C, Sarkar A, Deshpande P, Kango-Singh M, Singh A (2020) A two-clone approach to study signaling interactions among neuronal cells in a pre-clinical Alzheimer's disease model. iScience 23(12):101823.  [Abstract]
Tare M, Chimata AV, Gogia N, Narwal S, Deshpande P, Singh A (2020) An E3 ubiquitin ligase, cullin4 regulates retinal differentiation in Drosophila eye. Genesis 58(10-11):e23395.  [Abstract]
Irwin M, Tare M, Singh A, Puli OR, Gogia N, Riccetti M, Deshpande P , Kango-Singh M, and Singh A (2020) A positive feedback loop of Hippo- and c Jun-amino-terminal Kinase (JNK) signaling- pathways regulate Amyloid- beta mediated neurodegeneration. Frontiers in Cell and Developmental Biology: Cellular Biochemistry 8:117:doi: 10.3389/fcell.2020.00117.  [Abstract]
Gogia N, Sarkar A, Mehta A, Ramesh N, Deshpande P , Kango-Singh M, Pandey UB, and Singh A (2020) Inactivation of Hippo and cJun-N-terminal Kinase (JNK) signaling mitigate FUS mediated neurodegeneration in vivo. Neurobiology of Disease 140:104837:doi: 10.1016/j.nbd.2020.104837.  [Abstract]
Deshpande P, Chimata AV, Singh A (2020) An undergraduate cell biology laboratory exercise of Nile Red staining to mark lipid droplets in fly eye model of neurodegeneration. Drosophila Information Service 103:.  
Deshpande P, Gogia N. and Singh A (2019) Exploring the efficacy of natural products in alleviating Alzheimer's disease. Neural Regeneration Research 14(8):1321-29.  [Abstract]

Last Modified 12-04-2023

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