Bellen Lab

Shenzhao Lu

Shenzhao Lu

BS, Sichuan University, China
PhD, Institute of Neuroscience, University of Chinese Academy of Sciences, China (Jiawei Zhou)

Research Interests

The fruit fly, Drosophila melanogaster, looks so different from humans. But most fundamental biological mechanisms and pathways are conserved between these species. Fruit fly has been proven as a valuable tool, enabling many important discoveries in neurological disease research. I'm interested in identifying genes involved in the undiagnosed diseases using fruit fly as a model organism. And also, I want to take advantage of this system to study the mechanisms underlying neurodegeneration, thus providing therapeutic strategies.


Ma M, Ganapathi M, Zheng Y, Tan KL, Kanca O, Bove KE, Quintanilla N, Sag SO, Temel SG, LeDuc CA, McPartland AJ, Pereira EM, Shen Y, Hagen J, Thomas CP, Galvan NTN, Pan X, Lu S, Rosenfeld JA, Calame DG, Wangler MF, Lupski JR, Pehlivan D, Hertel PM, Chung WK, Bellen HJ (2024) Homozygous missense variants in YKT6 result in loss of function and are associated with developmental delay, with or without severe infantile liver disease and risk for hepatocellular carcinoma. Genetics in Medicine :101125.  [Abstract]
Pan X, Tao AM, Lu S, Ma M, Hannan SB, Slaugh R, Drewes Williams S, O'Grady L, Kanca O, Person R, Carter MT, Platzer K, Schnabel F, Abou Jamra R, Roberts AE, Newburger JW, Revah-Politi A, Granadillo JL, Stegmann APA, Sinnema M, Accogli A, Salpietro V, Capra V, Ghaloul-Gonzalez L, Brueckner M, Simon MEH, Sweetser DA, Glinton KE, Kirk SE; Baylor College of Medicine Center for Precision Medicine Models; Wangler MF, Yamamoto S, Chung WK, Bellen HJ (2024) De novo variants in FRYL are associated with developmental delay, intellectual disability, and dysmorphic features. American Journal of Human Genetics 111(4):742-760.  [Abstract]
Ma M, Zheng Y, Lu S, Pan X, Worley KC, Burrage LC, Blieden LS, Allworth A, Chen WL, Merla G, Mandriani B, Rosenfeld JA, Li-Kroeger D, Dutta D, Yamamoto S, Wangler MF; Undiagnosed Diseases Network; Glass IA, Strohbehn S, Blue E, Prontera P, Lalani SR, Bellen HJ (2024) De novo variants in PLCG1 are associated with hearing impairment, ocular pathology, and cardiac defects. medRxiv :10.1101/2024.01.08.23300523.  [Abstract]
Pan X, Alvarez AN, Ma M, Lu S, Crawford MW, Briere LC, Kanca O, Yamamoto S, Sweetser DA, Wilson JL, Napier RJ, Pruneda JN#, Bellen HJ# (2023) Allelic strengths of encephalopathy-associated UBA5 variants correlate between in vivo and in vitro assays. eLife 12:RP89891.  [Abstract]
Pan X, Dutta D, Lu S, Bellen HJ (2023) Sphingolipids in neurodegenerative diseases. Frontiers in Neuroscience 17:1137893.  [Abstract]
Chung HL, Ye Q, Park Y-J, Zuo Z, Kanca O, Mok J-W, Tattikota SG, Lu S, Perrimon N, Lee HK, Bellen HJ (2023) Very long-chain fatty acids induce glial-derived Sphingosine-1-Phosphate synthesis, secretion, and neuroinflammation. Cell Metabolism 35(5):855-874.  
Guichard A*, Lu S*, Kanca O*, Bressan D, Huang Y, Ma M, Sanz Juste S, Andrews JC, Jay K, Sneider M, Schwartz R, Huang MC, Bei D, Pan H, Ma L, Lin W-W, Auradkar A, Bhagwat P, Park S, Wan KH, Ohsako T, Takano-Shimizu T, Celniker SE, Wangler MF, Yamamoto S#, Bellen HJ#, Bier E# (2023) A comprehensive Drosophila resource to identify key functional interactions between SARS-CoV-2 factors and host proteins. Cell Reports 42(8):112842.  
Huang Y, Lemire G*, Briere LC*, Liu F, Wessels MW, Wang X, Osmond M,Kanca O, Lu S, High FA, Walker MA, Rodan LH, Undiagnosed Diseases Network, Care4Rare Canada Consortium, Kernohan KD, Sweetser DA, Boycott KM, Bellen HJ (2022) The recurrent de novo c.2011C>T missense variant in MTSS2 causes syndromic intellectual disability. American Journal of Human Genetics 109(11):2092. *contributed equally  [Abstract]
Ma M*, Zhang X*, Zheng Y, Lu S, Pan X, Mao X, Pan H, Chung HL, Wang H, Hong Guo H#, Bellen HJ# (2022) The fly homolog of SUPT16H, a gene associated with neurodevelopmental disorders, is required in a cell-autonomous fashion for cell survival. Human Molecular Genetics :DOI:10.1093/hmg/ddac259. *equal contribution. #co-corresponding authors [Abstract]
Lu S, Ma M, Mao X, Bacino CA, Jankovic J, Sutton VR, Bartley JA, Wang X, Rosenfeld JA, Beleza-Meireles A, Chauhan J, Pan X, Li M, Liu P, Prescott K, Amin S, Davies G, Wangler MF, Dai Y#, Bellen HJ# (2022) De novo variants in FRMD5 are associated with developmental delay, intellectual disability, ataxia and abnormalities of eye movement. American Journal of Human Genetics 109(10):1932-1943.  [Abstract]
Lu S*, Wu Y*, Guo Y*, Liang P*, Yin S*, Yin Y, Zhang X, Liu Y, Wang H, Xiao Y, Liang X, Zhou J (2022) Inhibition of astrocytic DRD2 suppresses CNS inflammation in an animal model of multiple sclerosis. Journal of Experimental Medicine :DOI: 10.1084/jem.20210998. *contributed equally [Abstract]
Ma M*, Moulton MJ*, Lu S, Bellen HJ (2022) 'Fly-ing' from rare to common neurodegenerative disease mechanisms. Trends in Genetics :DOI: 10.1016/j.tig.2022.03.018. *contributed equally [Abstract]
Lu S, Hernan R, Marcogliese PC, Huang Y, Gertler TS, Akcaboy M, Liu S, Chung H, Pan X, Sun X, Oguz M, Oztoprak U, de Baaij JHF, Ivanisevic J, McGinnis E, Guillen Sacoto MJ, Chung WK#, Bellen HJ# (2022) Loss of function variants in TIAM1 are associated with developmental delay, intellectual disability and seizures. AJHG :DOI: 10.1016/j.ajhg.2022.01.020. #co-corresponding [Abstract]
Accogli A*, Lu S*, Musante I*, Scudieri P, Rosenfeld JA, Severino M, Baldassari S, Iacomino M, Riva A, Balagura A, Piccolo G, Minetti C, Roberto D, Xia F, Razak R, Lawrence E, Hussein M, Chang EY, Holick M, Cali E, Aliberto E, Gambardella A, Emrick L, McCaffery PJA, Clagett-Dame M, Marcogliese PC, Bellen HJ, Lalani SR, Zara F, Striano P, Salpietro V (2022) Loss of Neuron Navigator 2 impairs brain and cerebellar development. Cerebellum :DOI: 10.1007/s12311-022-01379-3. *contributed equally [Abstract]
Goodman LD, Cope H, Nil Z, Ravenscroft, TA, Charng WL, Lu S, Tien AC, Pfundt R, Koolen DA, Haaxma CA, Veenstra-Knol HE, Wassink-Ruiter JSK, Wevers MR, Jones M, Walsh LE, Klee VH, Theunis M, Legius E, Steel D, Barwick KES, Kurian MA, Mohammad SS, Dale RC, Terhal PA, van Binsbergen E, Kirmse B, Robinette B, Cogne B, Isidor B, Grebe TA, Kulch P, Hainline BE, Sapp K, Morava E, Klee EW, Macke EL, Trapane P, Spencer C, Si Y, Begtrup A, Moulton MJ, Dutta D, Kanca O, UDN Consortia, Wangler MF, Yamamoto S, Bellen HJ*, Tan QKG*  (2021) De novo TNPO2 variants are associated with developmental delays, neurologic deficits and dysmorphic features in humans and alter TNPO2 activity in DrosophilaAmerican Journal of Human Genetics 108(9):1669-1691. *equal contribution [Abstract]
Lu SZ*, Guo YS, Liang PZ, Zhang SZ, Yin S, Yin YQ, Wang XM, Ding F, Gu XS, Zhou JW (2019) Suppression of astrocytic autophagy by αB-crystallin contributes to α-synuclein inclusion formation. Translational Neurodegeneration 8:3. (*equal contribution) [Abstract]
Guo YS, Liang PZ, Lu SZ, Chen R, Yin YQ, Zhou JW (2019) Extracellular αB-crystallin modulates the inflammatory responses. Biochemical and Biophysical Research Communications 508:282-288.  [Abstract]
Lu S, Zhou J (2017) Finding the 'Guilty' Gene Variant of Sporadic Parkinson's Disease Via CRISPR/Cas9. Neuroscience Bulletin 33:115-117.  [Abstract]
Huang Y, Ma M, Mao X, Pehlivan D, Kanca O, Un-Candan F, Shu L, Akay G, Mitani T, Lu S, Candan S, Wang H, Xiao B, Lupski JR, Bellen HJ (0) Novel dominant and recessive variants in human ROBO1 cause distinct neurodevelopmental defects through different mechanisms. Human Molecular Genetics : doi: 10.1093/hmg/ddac070.  [Abstract]

Last Modified 12-04-2023

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