Bellen Lab

Xueyang Pan

Xueyang Pan

BS, Peking University Health Science Center, Beijing, China
PhD, University of Minnesota, Minneapolis, Minnesota (Michael O'Connor)

Research Interests

I am interested in dissecting the genetic basis and the pathological changes in neurological diseases. I am part of the Model Organism Screening Center (MOSC) of the Undiagnosed Diseases Network (UDN). Using humanized fly models, I test the causative gene variants in patients, which provides support to the molecular diagnosis, and explore disease-causing mechanisms and potential therapeutic strategies. I am also studying the dysregulation of sphingolipid metabolism in the progression of neurodegenerative diseases including rare Mendelian diseases as well as Parkinson's Disease. Finally, I seek to identify novel inhibitors of sphingolipid biosynthetic enzyme, which could be developed into therapeutic reagents for the treatment of neurodegenerative diseases.


Ma M, Ganapathi M, Zheng Y, Tan KL, Kanca O, Bove KE, Quintanilla N, Sag SO, Temel SG, LeDuc CA, McPartland AJ, Pereira EM, Shen Y, Hagen J, Thomas CP, Galvan NTN, Pan X, Lu S, Rosenfeld JA, Calame DG, Wangler MF, Lupski JR, Pehlivan D, Hertel PM, Chung WK, Bellen HJ (2024) Homozygous missense variants in YKT6 result in loss of function and are associated with developmental delay, with or without severe infantile liver disease and risk for hepatocellular carcinoma. Genetics in Medicine :101125.  [Abstract]
Pan X, Tao AM, Lu S, Ma M, Hannan SB, Slaugh R, Drewes Williams S, O'Grady L, Kanca O, Person R, Carter MT, Platzer K, Schnabel F, Abou Jamra R, Roberts AE, Newburger JW, Revah-Politi A, Granadillo JL, Stegmann APA, Sinnema M, Accogli A, Salpietro V, Capra V, Ghaloul-Gonzalez L, Brueckner M, Simon MEH, Sweetser DA, Glinton KE, Kirk SE; Baylor College of Medicine Center for Precision Medicine Models; Wangler MF, Yamamoto S, Chung WK, Bellen HJ (2024) De novo variants in FRYL are associated with developmental delay, intellectual disability, and dysmorphic features. American Journal of Human Genetics 111(4):742-760.  [Abstract]
Ma M, Zheng Y, Lu S, Pan X, Worley KC, Burrage LC, Blieden LS, Allworth A, Chen WL, Merla G, Mandriani B, Rosenfeld JA, Li-Kroeger D, Dutta D, Yamamoto S, Wangler MF; Undiagnosed Diseases Network; Glass IA, Strohbehn S, Blue E, Prontera P, Lalani SR, Bellen HJ (2024) De novo variants in PLCG1 are associated with hearing impairment, ocular pathology, and cardiac defects. medRxiv :10.1101/2024.01.08.23300523.  [Abstract]
Pan X, Alvarez AN, Ma M, Lu S, Crawford MW, Briere LC, Kanca O, Yamamoto S, Sweetser DA, Wilson JL, Napier RJ, Pruneda JN#, Bellen HJ# (2023) Allelic strengths of encephalopathy-associated UBA5 variants correlate between in vivo and in vitro assays. eLife 12:RP89891.  [Abstract]
Pan X, Dutta D, Lu S, Bellen HJ (2023) Sphingolipids in neurodegenerative diseases. Frontiers in Neuroscience 17:1137893.  [Abstract]
Srivastava S, Shaked HM, Gable K, Gupta SD, Pan X, Somashekarappa N, Han G, Mohassel P, Gotkin3 M, Doney E, Goldenberg P, Tan QKG, Gong Y, Kleinstiver B, Wishart B, Cope H, Pires CB, Stutzman H, Spillmann RC, Undiagnosed Disease Network (UDN), Sadjadi R, Elpeleg O, Lee CH, Bellen HJ, Edvardon S, Eichler F, Dunn TM (2022) SPTSSA variants alter sphingolipid synthesis and cause a complex hereditary spastic paraplegia. Brain :awac460. doi: 10.1093/brain/awac460.  [Abstract]
Ma M*, Zhang X*, Zheng Y, Lu S, Pan X, Mao X, Pan H, Chung HL, Wang H, Hong Guo H#, Bellen HJ# (2022) The fly homolog of SUPT16H, a gene associated with neurodevelopmental disorders, is required in a cell-autonomous fashion for cell survival. Human Molecular Genetics :DOI:10.1093/hmg/ddac259. *equal contribution. #co-corresponding authors [Abstract]
Lu S, Herman R, Marcogliese PC, Huang Y, Gertler TS, Akcaboy M, Liu S, Chung HL, Pan X, Sun X, Oguz M, Oztoprak U, deBaaij JHF, Ivanisevic J, McGinnis E, Guillen Sacoto MJ, Chung WK#, Bellen HJ# (2022) Loss of function variants in TIAM1 are associated with developmental delay, intellectual disability and seizures. AJHG :DOI: 10.1016/j.ajhg.2022.01.020. # co-corresponding  [Abstract]
Li X, Yang L, Mao Z, Pan X, Zhao Y, Gu X, Eckel-Mahan K, Zuo Z, Tong Q, Hartig SM, Cheng X, Du G, Moore DD, Bellen HJ, Sesaki H, Sun K (2020) Novel role of dynamin-related-protein 1 in dynamics of ER-lipid droplets in adipose tissue. FASEB Journal 34:8265-8282.  [Abstract]
Moss-Taylor L, Upadhyay A, Pan X, Kim M-J, O'Connor MB (2019) Motoneuron derived Activin beta regulates Drosophila body size and tissue scaling. Genetics 213:1447-1464.  [Abstract]
Pan X, Neufeld TP, O'Connor MB  (2019) A tissue- and temporal-specific autophagic switch controls Drosophila pre-metamorphic nutritional checkpoints. Current Biology 29:2840-2851.  [Abstract]
Pan X, O'Connor MB (2019) Developmental Maturation: Drosophila AstA Signaling Provides a Kiss to Grow Up.  29:R161-R164.  [Abstract]
Setiawan L, Pan X, Woods AL, O'Connor MB, Hariharan IK  (2018) The BMP2/4 ortholog Dpp can function as an inter-organ signal that regulates developmental timing. Life Science Alliance 1:e201800216.  [Abstract]
Shimell M, Pan X, Martin FA, Ghosh AC, Leopold P, O'Connor MB, Romero NM (2018) Prothoracicotropic hormone modulates environmental adaptive plasticity through the control of developmental timing. Development . Development 145:dev159699.  [Abstract]
Zhang J, An Y, Gao J, Han J, Pan X, Pan Y, Tie L, Li X  (2012) Aquaporin-1 translocation and degradation mediates the water transportation mechanism of acetazolamide. PLoS One 7(9):e45976.  [Abstract]
Han J, Pan X, Xu Y, Xiao Y, An Y, Tie L, Pan Y, Li X  (2012) Curcumin induces autophagy to protect vascular endothelial cell survival from oxidative stress damage. Autophagy 8(5):812-825.  [Abstract]
Pan X, Guo H, Han J, Hao F, An Y, Xu Y, Xiaokaiti Y, Pan Y, Li X  (2012) Ginsenoside Rg3 attenuates cell migration via inhibition of aquaporin 1 expression in PC-3M prostate cancer cells. European Journal of Pharmacology 683(1-3):27-34.  [Abstract]
Pan Y, Lei T, Teng B, Liu J, Zhang J, An Y, Xiao Y, Han J, Pan X, Wang J, Yu H, Ren H, Li X  (2011) ) Role of vimentin in the inhibitory effects of low-molecular-weight heparin on PC-3M cell adhesion to, and migration through, endothelium. Journal of Pharmacology and Experimental Therapeutics 339(1):82-92.  [Abstract]
Wang R, Li Y, Xu Y, Li Y, Wu H, Guo H, Zhang J, Zhang J, Pan X, Li X  (2010) Curcumin produces neuroprotective effects via activating brain-derived neurotrophic factor/TrkB-dependent MAPK and PI-3K cascades in rodent cortical neurons. Progress in Neuro-Psychopharmacology and Biological Psychiatry 34(1):147-153.  [Abstract]

Last Modified 12-04-2023

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