Bellen Lab

Yohei Nitta

Yohei Nitta

PhD., University of Tokyo
MS., University of Tokyo
B.S., Tokyo University of Agriculture and Technology

Research Interests

I have studied neural development and neurodegeneration using Drosophila. Through this research, I became deeply interested in the relationship between lipid metabolism and neurodegenerative diseases such as AD and PD. Despite lipids comprising 60% of the human brain, their functions remain largely unexplored due to the difficulty of analysis. By combining the genetics of Drosophila and lipidomics, I'd like to elucidate the role of lipids in maintaining neural health. Additionally, I am already engaged in studying undiagnosed diseases using Drosophila, to elucidate deeper pathological mechanisms and identify therapeutic targets for these diseases. By researching lipid metabolism abnormality-related neurodegeneration and rare diseases, I hope to contribute to a better understanding of common diseases.

Publications

Nitta Y., Osaka J., Maki R., Hakeda-Suzuki S., Suzuki E., Ueki S., Suzuki T. Sugie A.  (2024) Drosophila model to clarify the pathological significance of OPA1 in autosomal dominant optic atrophy . eLife 12:RP87880.  [Abstract]
Chauvin SD, Ando S, Holley JA, Sugie A, Zhao FR, Poddar S, Kato R, Miner CA, Nitta Y, Krishnamurthy SR, Saito R, Ning Y, Hatano Y, Kitahara S, Koide S, Stinson WA, Fu J, Surve N, Kumble L, Qian W, Polishchuk O, Andhey PS, Chiang C, Liu G, Colombeau L, Rodriguez R, Manel N, Kakita A, Artyomov MN, Schultz DC, Coates PT, Roberson EDO, Belkaid Y, Greenberg RA, Cherry S, Gack MU, Hardy T, Onodera O, Kato T, Miner JJ.  (2024) Inherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humans. Nat Commun 15:4696.  [Abstract]
Iida T, Igarashi A, Fukunaga K, Aoki T, Hidai T, Yanagi K, Yamamori M, Satou K, Go H, Kosho T, Maki R, Suzuki T, Nitta Y, Sugie A, Asaoka Y, Furutani-Seiki M, Kimura T, Matsubara Y, Kaname T.  (2024) Functional analysis of RRAS2 pathogenic variants with a Noonan-like phenotype. Front Genet 15:1383176.  [Abstract]
Vetro A., Pelorosso C., Balestrini S., [and 121 others, including Nitta Y.] (2023) Stretch-activated ion channel TMEM63B associates with developmental and epileptic encephalopathies and progressive neurodegeneration . The American Journal of Human Genetics 110(8):1356-1376.  [Abstract]
Yamada M*., Nitta Y*., Uehara T., Suzuki H., Miya F., Takenouchi T., Tamura M., Ayabe Y., Yoshiki A., Maeno A., Saga Y., Furuse T., Yamada I., Okamoto N., Kosaki K., Sugie A. (2023) Heterozygous loss-of-function DHX9 variants are associated with neurodevelopmental disorders: Human genetic and experimental evidences . European Journal of Medical Genetics 66(8):104804. * co-first author [Abstract]
Osaka J., Yasuda H., Watanuki Y., Kato Y., Nitta Y., Sugie A., Sato M., Suzuki T.  (2023) Identification of genes regulating stimulus-dependent synaptic assembly in Drosophila using an automated synapse quantification system . Genes & Genetic Systems 97(6):297-309.  [Abstract]
Itai T., Sugie A., Nitta Y., Maki R., Suzuki T., Shinkai Y., Watanabe Y., Nakano Y., Ichikawa K., Okamoto N., Utsuno Y., Koshimizu E., Fujita A., Hamanaka K., Uchiyama Y., Tsuchida N., Miyake N., Misawa K., Mizuguchi T., Miyatake S., Matsumoto N.  (2023) A novel NONO variant that causes developmental delay and cardiac phenotypes. Scientific Reports 13(1):975.  [Abstract]
Nitta Y., Kawai H., Maki R., Osaka J., Hakeda-Suzuki S., Nagai Y., Doubkova K., Uehara T., Watanabe K., Kosaki K., Suzuki T., Tavosanis G., Sugie A.  (2023) Direct evaluation of neuroaxonal degeneration with the causative genes of neurodegenerative diseases in drosophila using the automated axon quantification system, MeDUsA. Human Molecular Genetics 32(9):1524-1538.  [Abstract]
Nitta Y., Sugie A.  (2022) Studies of neurodegenerative diseases using Drosophila and the development of novel approaches for their analysis . Fly(Austin) 16(1):275-298.  [Abstract]
Richard M., Doubkova K., Nitta Y., Kawai H., Sugie A., Tavosanis G. (2022) A Quantitative Model of Sporadic Axonal Degeneration in the Drosophila Visual System. The Journal of neuroscience 42(24):4937-4952.  [Abstract]
Sakamoto M., Sasaki K., Sugie A., Nitta Y., Kimura T., Gursoy S., Cinleti T., Iai M., Sengoku T., Ogata K., Suzuki A., Okamoto N., Iwama K., Tsuchida N., Uchiyama Y., Koshimizu E., Fujita A., Hamanaka K., Miyatake S., Mizuguchi T., Taguri M., Ito S., Takahashi H., Miyake N., Matsumoto N.  (2021) De novo ARF3 variants cause neurodevelopmental disorder with brain abnormality . Human molecular genetics 31(1):69-81.  [Abstract]
Takechi H., Hakeda-Suzuki S., Nitta Y., Ishiwata Y., Iwanaga R., Sato M., Sugie A., Suzuki T. (2021) Glial insulin regulates cooperative or antagonistic Golden goal/Flamingo interactions during photoreceptor axon guidance. eLife 10:e66718.  [Abstract]
Nyuzuki H., Ito S., Nagasaki K., Nitta Y., Matsui N., Saitoh A., Matsui H.  (2020) Degeneration of dopaminergic neurons and impaired intracellular trafficking in Atp13a2 deficient zebrafish . IBRO Reports 9:1-8.  [Abstract]
Nitta Y., Matsui S., Kato Y., Kaga Y., Sugimoto K., Sugie A. (2019) Analysing the evolutional and functional differentiation of four types of Daphnia magna cryptochrome in Drosophila circadian clock. Scientific Reports 9:8857.  [Abstract]
Nitta Y.*, Sugie A.*  (2017) DISCO interacting protein 2 determines direction of axon projection under the regulation of c-Jun N-terminal kinase in the Drosophila mushroom body . Biochemical and Biophysical Research Communications 487(1):116-121 . * co-corresponding author [Abstract]
Nitta Y.*, Sugie A.*  (2017) Identification of glaikit in a genome-wide expression profiling for axonal bifurcation of the mushroom body in Drosophila . Biochemical and Biophysical Research Communications 487(4):898-902 . * co-corresponding author [Abstract]
Nitta Y., Yamazaki D., Sugie A., Hiroi M., Tabata T.  (2017) DISCO Interacting Protein 2 regulates axonal bifurcation and guidance of Drosophila mushroom body neurons . Developmental Biology 421(2):233-244.  [Abstract]
Abe T., Yamazaki D., Murakami S., Hiroi M., Nitta Y., Maeyama Y., Tabata T.  (2014) The NAV2 homolog Sickie regulates F-actin-mediated axonal growth in Drosophila mushroom body neurons via the non-canonical Rac-Cofilin pathway. Development 141(24):4716-4728.  [Abstract]
Last Modified 12-04-2023

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