Bellen Lab

Yun Zhao

Yun Zhao

BS, Zhengzhou University, China
PhD, Peking University, China

Research Interests

I am interested in the mechanisms and potential therapeutic strategies for neurodegenerative diseases. Using Drosophila as my primary model system, I investigate the roles of disease-associated genes in the onset and progression of neurodegeneration. I am also interested in rare diseases, aiming to better understand neurodegenerative processes by exploring the association between identified clinical phenotypes and their underlying genetic variations.


Publications

Zhao Y*, Xiong C*, Wang B, Li D, Liu J, Wei S, Hou Y, Zhou Y#, Zheng R# (2025) The Discovery of Phages in the Substantia Nigra and Its Implication for Parkinson's Disease. Research 8:0657. * equal contribution # co-corresponding authors [Abstract]
Wang B, Hu Z, Cui L, Zhao M, Su Z, Jiang Y, Liu J, Zhao Y, Hou Y, Yang X, Zhang C, Guo B, Li D, Zhao L, Zheng S, Zhao Y, Yang W, Wang D, Yu S, Zhu S, Yan Y, Yuan G, Li K, Zhang W, Qin L, Zhang W, Sun F, Luo J, Zheng R (2024) BetaAR-mTOR-lipin1 pathway mediates PKA-RIIBeta deficiency-induced adipose browning. Theranostics 14(13):5316-5335.  [Abstract]
Zhao Y, Wang B, Zhao M, Liu J, Hou Y, Wei S, Xiong C, Li D, Zheng R (2024) Age-related decline of PKA-RIIBeta level in SNc dopaminergic neurons underlies PD pathogenesis. bioRxiv DOI:10.1101/2024.09.13.612981.  
Liu J, Wang B, Su Z, Han X, He M, Zhao Y, Hou Y, Li D, Zhang W, Qin L, Wang K, Li Y, Yan Y, Yu S, Huang X, Yuwen T, Zheng R (2024) Identification of leptolin as a novel anti-obesity adipokine. bioRxiv DOI:10.1101/2024.09.03.610963.  
Wang B, Zhao M, Su Z, Jin B, Yang X, Zhang C, Guo B, Li J, Hong W, Liu J, Zhao Y, Hou Y, Lai F, Zhang W, Qin L, Zhang W, Luo J, Zheng R (2023) RIIBeta-PKA in GABAergic Neurons of Dorsal Median Hypothalamus Governs White Adipose Browning. Advanced Science 10(5):e2205173.  [Abstract]
Zhao M, Wang B, Zhang C, Su Z, Guo B, Zhao Y, Zheng R (2021) The DJ1-Nrf2-STING axis mediates the neuroprotective effects of Withaferin A in Parkinson's disease. Cell Death & Differentiation 28(8):2517-2535.  [Abstract]
Ren X, Zhao Y, Xue F, Zheng Y, Huang H, Wang W, Chang Y, Yang H, Zhang J (2019) Exosomal DNA Aptamer Targeting alpha-Synuclein Aggregates Reduced Neuropathological Deficits in a Mouse Parkinson's Disease Model. Molecular Therapy Nucleic Acids 17:726-740.  [Abstract]

Last Modified 12-04-2023

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