Bellen Lab

Ziyaneh Ghaderpour Taleghani

Ziyaneh Ghaderpour Taleghani

BS, University of Michigan-Ann Arbor, MI


Research Interests

I am interested in understanding what rare neurological diseases can teach us about mechanisms of neuronal function and cognition. Under the guidance of Dr. Lindsey Goodman, I am studying the cargo shuttling importin Transportin 2 (Tnpo2) and its role in human health, particularly within the brain. TNPO2 disease is rare and characterized by various physical and neurological defects; because the mechanisms of this disease are not clear, there are few effective treatments available for patients. To understand how TNPO2 functions in health and disease, I am focused on characterizing variant proteins and their aberrant function in both Drosophila and human cell culture. My hope is that our findings can help patient families understand their disease, and that our work can be used by health professionals to provide more effective patient therapies.


Publications

Goodman LD, Ralhan I, Li X, Lu S, Moulton MJ, Park YJ, Zhao P, Kanca O, Ghaderpour Taleghani ZS, Jacquemyn J, Shulman JM, Ando K, Sun K, Ioannou MS, Bellen HJ (2024) Tau is required for glial lipid droplet formation and resistance to neuronal oxidative stress. Nature Neuroscience :Epub ahead of print.  [Abstract]

Last Modified 12-04-2023

top ↑